Thursday Night NFL Best Bets

September 25, 2025

Thursday Night Football Betting Preview: Seahawks vs. Cardinals

Week 4 kicks off tonight in the NFC West as the Seattle Seahawks host the Arizona Cardinals. Seattle looks to keep momentum rolling at home, while Arizona tries to find answers after losing key pieces like RB James Conner.

The line sits at Seahawks –1.5 with a total around 43.5 points. Let’s break down the best ways to attack this matchup.

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