Thursday Night Football Best Bets

October 02, 2025

Thursday Night Football Preview: Rams vs. 49ers

Week 5 brings us an NFC West showdown as the Los Angeles Rams host the San Francisco 49ers. Both teams are dealing with significant injuries, but the circumstances point to a clear edge for LA tonight.

🏈 Game Context

  • 49ers: Starting QB Brock Purdy is out with a toe injury, leaving backup Mac Jones to face a strong Rams defense. Receivers Jauan Jennings and rookie Ricky Pearsall are also sidelined, further limiting San Francisco’s passing attack.

  • Rams: While TE Tyler Higbee and RT Rob Havenstein are doubtful, QB Matthew Stafford still has his top weapon in Puka Nacua, who has been a target machine all season.

  • Line/Total: Rams –8.5 | O/U 44.5

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